On Monotonicities of Interval Valued Functions

In this paper, we develop the notions of weak/directional monotonicity (developed by Sesma-Sara et al. in terms of the \emph{Kulisch-Miranker order}) and the notion of $G$-monotonicity (introduced by Santiago et al. for $[0,\!1]$) for intervals endowed with admissible orders.Comment: 3 page

Extension of Quasi-Overlap and Quasi-Grouping Functions Defined on Bounded Lattices Via Retractions

In this paper, we propose a method of extending quasi-overlap and grouping functions defined on a sublattice $M$ of a bounded lattice $L$ to this lattice considering a more general version of sublattice definition, introduced by Palmeira and Bedregral

Abstract homogeneity of interval-valued functions

In this paper we develop the idea of abstract homogeneity in the context of interval-valued (IV) functions endowed with admissible orders and investigate some of its properties.Comment: 2 page

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Fatores que contribuem para o desmame precoce Factores que contribuyen para el destete precoz Factors that contribute to early weaning

A interrupção prematura da amamentação pode acarretar perigos, pois os alimentos a serem utilizados são inadequados do ponto de vista nutricional, além de expor a criança a organismos infecciosos. Torna-se relevante investigar os fatores relacionados ao desmame precoce. Pesquisa exploratória e quantitativa, realizada no Centro de Desenvolvimento da Família (CEDEFAM), no período de maio a junho/2003, com 20 nutrizes, no qual foi aplicado um questionário contendo 12 questões sobre os motivos que as levaram a desmamarem precocemente. Os resultados foram agrupados em três segmentos: fatores de desmame relacionados com o perfil; a assistência pré-natal e o parto; e prática do aleitamento materno, e apresentados em forma de tabelas. Concluímos que os profissionais e a sociedade podem não estar preparados para favorecer a mulher no exercício da amamentação. Enquanto isso, a política de saúde não cria condições para que todos tenham acesso à educação, melhoria de renda e conscientização do planejamento familiar.<br>La interrupción precoz del destete puede resultar en peligros, pues los alimentos utilizados son considerados por los nuticionistas como inadecuados, además de exponer al niño a organismos infecciosos. Es muy importante investigar los factores relacionados al desmame. Investigación exploratoria y cuantitativa, realizada en una Unidad de Desarrollo de la Família (CEDEFAM), en el período de mayo hasta junio/2003, con 20 nutrices, cuando fue aplicado un cuestionardo com 12 cuestiones sobre los motivos que que las llevaron al destete precoz. Los resultados fueron agrupados en tres segmentos: factores de destete relacionados con el perfil; la asistencia prenatal y el parto; y práctica de la amamantación materna, y presentados en forma de tabelas. Concluimos que los profesionales y la sociedad pueden no estar preparados para faborecer la mujer en amamantación. Mientras eso ocurre, la política de salud no crea condiciones para que todos tengan acceso a la educación, mejoria de salario y conciencia de la planificación familiar.<br>The premature interruption of breast-feeding can cause danger, as the food that is used is inadequate as to the nutritional point of view, besides exposing the child to infectious organisms. It becomes relevant to investigate the factors related to weaning. Exploratory and quantitative research, carried out in the Family Development Center (CEDEFAM) in the period from May to June/2003, with twenty mothers who answered a questionnaire containing twelve questions about the reasons that led them to wean early. The results were grouped into three categories, presented in the form of charts. We concluded that professionals and society may not be prepared to favor the woman in the exercise of breast-feeding. Meanwhile, health policies do not create the conditions so that everyone can have access to education, income rise and understanding of family planning

Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury

Although mesenchymal stromal (stem) cell (MSC) administration attenuates sepsis-induced lung injury in pre-clinical models, the mechanism(s) of action and host immune system contributions to its therapeutic effects remain elusive. We show that treatment with MSCs decreased expression of host-derived microRNA (miR)-193b-5p and increased expression of its target gene, the tight junctional protein occludin (Ocln), in lungs from septic mice. Mutating the Ocln 3′ untranslated region miR-193b-5p binding sequence impaired binding to Ocln mRNA. Inhibition of miR-193b-5p in human primary pulmonary microvascular endothelial cells prevents tumour necrosis factor (TNF)-induced decrease in Ocln gene and protein expression and loss of barrier function. MSC-conditioned media mitigated TNF-induced miR-193b-5p upregulation and Ocln downregulation in vitro. When administered in vivo, MSC-conditioned media recapitulated the effects of MSC administration on pulmonary miR-193b-5p and Ocln expression. MiR-193b-deficient mice were resistant to pulmonary inflammation and injury induced by lipopolysaccharide (LPS) instillation. Silencing of Ocln in miR-193b-deficient mice partially recovered the susceptibility to LPS-induced lung injury. In vivo inhibition of miR-193b-5p protected mice from endotoxin-induced lung injury. Finally, the clinical significance of these results was supported by the finding of increased miR-193b-5p expression levels in lung autopsy samples from acute respiratory distress syndrome patients who died with diffuse alveolar damage.Canadian Institutes of Health Research (CIHR) (MOP-130331; MPO-106545)Ontario Research Fund (RE07-086)Ontario Graduate ScholarshipSt. Michael's Hospital Li Ka Shing Knowledge Institute Graduate ScholarshipMary J. Santalo Fellowship33.809 JCR (2021) Q1, 2/65 Respiratory System4.336 SJR (2021) Q1, 46/24989 Medicine (Miscellaneous)No data IDR 2021UE

Optimization of the Effects of Different Temperatures and Compositions of Filmogenic Solution on Lactobacillus salivarius Using Predictive Mathematical Models

It is well known that intake of probiotic brings health benefits. Lactic bacteria with probiotic potential have aroused the interest of the industry in developing food products that incorporate such benefits. However, incorporating probiotic bacteria into food is a challenge for the industry, given the sensitivity of probiotic cultures to process conditions. Therefore, the objective of this study is to evaluate gelatin- and inulin-based filmogenic solutions as a potential vehicle for incorporating probiotics into food products and to model the fermentation kinetics. L. salivarius (Lactobacillus salivarius) growth in filmogenic solutions was analyzed under the influence of a variety gelatin concentrations (1.0&ndash;3.0%) and inulin concentrations (4.0&ndash;6.0%) and fermented under the effect of different temperatures (25&ndash;45 &deg;C). A full 23 factorial plan with three replicates at the central point was used to optimize the process. The impacts of process conditions on cell development are fundamental to optimize the process and make it applicable by the industry. The present study showed that the optimal conditions for the development of probiotic cells in filmogenic solutions are a combination of 1.0% gelatin with 4.0% inulin and fermentation temperature of 45 &deg;C. It was observed that the maximum cell growth occurred in an estimated time of about 4 h of fermentation. L. salivarius cell production and substrate consumption during the fermentation of the filmogenic solution were well simulated by a model proposed in this article, with coefficients of determination of 0.981 (cell growth) and 0.991 (substrate consumption)

A geometrically exact finite beam element formulation for thin film adhesion and debonding

Objectives. TO investigate intra- and interexaminers' reproducibility of usual adenoid hypertrophy assessment methods, according to nasofiberendoscopic eXamination.Methods. Forty children of both sexes, ages ranging between 4 and 14 years, presenting with nasal obstruction and oral breathing suspected to be caused by adenoid hypertrophy, were enrolled in this study, Patients were evaluated by nasofiberendoscopy, and records were referred to and evaluated by two experienced otolaryngologists. Examiners analysed the records according to different evaluation methods; i.e., estimated, and measured percentage of choanal occlusion; as well as Subjective and objective classificatory systems of adenoid hypertrophy.Results. Data disclosed excellent intraexarniner reproducibility for both estimated and measured choanal occlusion. Interexaminers analysis revealed lower reproducibility rates of estimated in relation to measured choanal occlusion. Measured choanal occlusion also demonstrated less agreement among evaluations made through the right and left sides of the nasal cavity. Alternatively, intra- and interexaminers reliability analysis revealed higher agreement for subjective than objective classificatory system. Besides, subjective method demonstrated higher agreement than the objective classificatory system, when opposite sides were compared.Conclusion. Our results suggest that Measured is superior to estimated percentage of choanal occlusion, particularly if employed bilaterally, diminishing the lack of agreement between sides. When adenoid categorization is used instead, the authors recommend Subjective rather than objective classificatory system of adenoid hypertrophy